Posts Tagged ‘POH’

Share Purchase Plan: Phosphagenics

Monday, October 24th, 2011

Phosphagenics (POH) announced on the 21/10/2011 that they would be conducting a Share Purchase Plan to raise additional capital. The record date was the 20/10/2011 on which shareholders must own the share to participate in the SPP. The closing date is 7/11/2011.  Shares will be issued on 11/11/2011 and begin trading on 14/11/2011.    A maximum of $15,000 can be purchased by each shareholder at $0.14.

Discount :  12.5% Liquidity : Poor Profitability : Poor  Stability : Poor

*Note: Discount is based on the closing price on the 21 October 2011.

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ASX Company News: Phosphagenics Enters Joint Venture For New Cosmetic Product

Thursday, September 15th, 2011

Melbourne drug delivery technology company Phosphagenics Limited (POH) has entered into an agreement with a leading global cosmetic and dermatology company to conduct a human study on a new cosmetic product incorporating its TPM® platform delivery system.

Phosphagenics’ CEO, Dr Esra Ogru, said the partnership with another leading cosmetic, high-caliber company is further endorsement of the efficacy of the company’s platform technology. “There is growing recognition from leading global cosmetics and dermatology companies that TPM® can be a major point of difference for them in the marketplace,” she said. “We have consistently demonstrated that TPM® enables superior delivery of active ingredients topically and transdermally and have proven the versatility of this technology by applying it both to cosmetic and pharmaceutical compounds.”

Phosphagenics is commercialising drug delivery applications based on its novel transdermal (drugs administered via skin) TPM® – Targeted Penetration Matrix technology. TPM® is a patient friendly and cost effective system used to deliver proven pharmaceutical and nutraceutical products. The lead product advancing through clinical trials is an oxycodone matrix system for the relief of chronic pain.

www.phosphagenics.com

www.elixia.com.au

http://www.traderdealer.com.au/fundamentals/poh

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ASX Company News: Phosphagenics Enters Asian Distribution Agreement

Wednesday, August 3rd, 2011

Melbourne biotechnology company Phosphagenics Limited (POH) has signed an agreement with a leading Asian distributor ensuring its Elixia® personal care range will be available in stores across the Asia Pacific region by the fourth quarter, 2011. The milestone distribution deal has been struck with the Sungate Supplies Pte Ltd, which will exclusively supply AS Watson and Company stores commencing in Singapore. A.S. Watson & Co. is a retail and consumer division of the Hong Kong based conglomerate Hutchison Whampoa Ltd, and over the past decade has become the  largest health and beauty retailer in the world with over 7,000 stores.

Announcing the agreement, Phosphagenics CEO, Dr Esra Ogru, said while the Elixia® ranges had recently achieved Australian sales target of $1 million, the Asian region “is the fastest growing skincare market in the world. In 2010 skincare sales across the region generated $37.4 billion,” she noted. “We are very excited about this milestone. This is in-line with our strategy to become an international skincare brand. We are continuing to pursue other opportunities in the Asia region as well as Europe and the US. Phosphagenics is on track to meet its stated goal of becoming financially independent by the end of 2012” said Dr Ogru.

Elixia® is an Australian owned and developed brand which includes anti-ageing skincare formulas, specially developed to penetrate and target fine lines and wrinkles. The active anti-ageing ingredients include SNAP-8, Carnosine and CoQ10. TPM® is a patented world first delivery technology which enables superior penetration of these active ingredients into the skin.

Phosphagenics is commercialising drug delivery applications based on its novel transdermal (drugs administered via skin) TPM® – Targeted Penetration Matrix technology. TPM® is a patient friendly and cost effective system used to deliver proven pharmaceutical and nutraceutical products. The lead product advancing through clinical trials is an oxycodone matrix system for the relief of chronic pain.

www.phosphagenics.com

www.elixia.com.au

http://www.traderdealer.com.au/fundamentals/poh

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ASX Company News: Phosphagenics Enters Asian Distribution Agreement

Thursday, July 7th, 2011

Phosphagenics Limited (POH) has signed an agreement with a leading Asian distributor ensuring its Elixia personal care range will be available in stores across the ® Asia Pacific region by the fourth quarter, 2011. The milestone distribution deal has been struck with the Sungate Supplies Pte Ltd, which will exclusively supply AS Watson and Company stores commencing in Singapore. A.S. Watson & Co. is a retail and consumer division of the Hong Kong based conglomerate Hutchison Whampoa Ltd, and over the past decade has become the largest health and beauty retailer in the world with over 7,000 stores.

Announcing the agreement, Phosphagenics CEO, Dr Esra Ogru, said while the Elixia ® ranges had recently achieved Australian sales target of $1 million, the Asian region “is the fastest growing skincare market in the world.   In 2010 skincare sales across the region generated $37.4 billion,” she noted. “We are very excited about this milestone.  This is in-line with our strategy to become an international skincare brand.  We are continuing to pursue other opportunities in the Asia region as well as Europe and the US.  Phosphagenics is on track to meet its stated goal of becoming financially independent by the end of 2012” said Dr Ogru.  Cathy Yeap, the Managing Director of AS Watson, Singapore said “We are very excited to be involved in the Asian launch of Elixia® through our stores and we anticipate that we will replicate the very successful launch of the products in Australia.”

Phosphagenics is commercialising drug delivery applications based on its novel transdermal (drugs administered via skin) TPM® – Targeted Penetration Matrix technology.  TPM® is a patient friendly and cost effective system used to deliver proven

pharmaceutical and nutraceutical products. The lead product advancing through clinical trials is an oxycodone matrix system for the relief of chronic pain.

www.phosphagenics.com

www.elixia.com.au

http://www.traderdealer.com.au/fundamentals/poh

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ASX Company News: Calzada and Phosphagenics Enter Cosmeceutical JV Agreement

Wednesday, October 20th, 2010

Calzada Limited (CZD) is pleased to announce that the company has today signed a licensing deal with Melbourne biotechnology company Phosphagenics Limited (POH) to launch a cosmeceutical product containing Calzada’s anti anti-obesity peptide, known as AOD9604, in combination with Phosphagenics’ TPMTM technology. Phosphagenics has completed formulation, development and testing, successfully demonstrating increased skin absorption of AOD9604. Human studies of the novel TPMTM/anti peptide product will be conducted in Australia to study the efficacy of TPMTM/anti- fat of the cosmeceutical product, with Phosphagenics on track to launch the product to world markets as a cosmetic in early 2011.

AOD9604 is a 16 amino acid peptide derived from human growth hormone that has undergone pre undergone pre-clinical and clinical testing in multiple human trials in an oral dosage form. In a large phase 2 human trial AOD9604 was unable to demonstrate weight loss across the entire study population, although some positive weight loss was evident in a large female sub-group. The Phosphagenics commercial strategy is to re formulate the oral compound into a topical cream utilizing re-formulate TPMTM for cosmetic application. TPMTM has reproducibly shown the ability to deliver   range of different actives into the skin, including proteins significantly larger than AOD9604. It is anticipated this approach will enhance the delivery of AOD9604 directly to problem areas, circumventing the need for oral absorption.

Announcing the new licensing deal, Phosphagenics CEO Dr Esra Ogru said, “There is little doubt that the compound has huge potential. Topical delivery could by pass earlier problems associated with oral absorption by-pass and efficacy of AOD9604.” She said the company had already sourced the peptide from a low-cost Asian manufacturer, had formulated and cost developed a topical product using TPMTM. Phosphagenics has mapped out a commercial and marketing strategy for the product and expects these activities to commence in early 2011 through multiple distribution channels.  Dr Ogru said the existing cosmetic market is very large with around $US3 billion spent globally each year on products that promise “firming” or anti-cellulite results. She said “Phosphagenics’ TPMTM delivery technology is backed by solid scientific and clinical data which clearly Phosphagenics’ scientific differentiates our new offering from the leading products in the cosmetic sector.”

www.metabolic.com.au/

http://www.traderdealer.com.au/Fundamentals/czd

www.phosphagenics.com

http://www.traderdealer.com.au/Fundamentals/poh

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Phosphagenics Launches Skin Care Range

Thursday, February 4th, 2010

Phosphagenics Limited (POH) has signed an agreement appointing Pulse Pharmacies as its exclusive Australia-wide distributer of Phosphagenics’ new Elixia™ skincare product range.

The Elixia™ range of six products, including an Anti-oxidant Serum and a Multi V Moisturiser, uses the Phosphagenics patented TPM™ (Targeted Penetration Matrix) delivery technology to deliver more active ingredients into the skin.

According to Phosphagenics’ Chief Operating Officer, Dr Esra Ogru, the patented TPM™ delivery technology has demonstrated in many human clinical trials that it can increase the amount and depth of penetration of active molecules into the skin including drugs such as insulin and opioids. “The technology lends itself perfectly to skin care, and the inclusion of TPM™ within the Elixia range will increase the absorption of active ingredients used in the cosmetic industry, compared to other marketed topical applications.” She added, “Elixia™ will take advantage of TPM’s scientifically proven ability to increase the absorption of valuable molecules from our vitamin-rich formulas. While comparator products may contain similar ingredients, we know TPM™ will ensure they don’t sit on the skin surface and will reach the layers of skin that will benefit from their activity.”

The Elixia™ skincare range is expected to be available for purchase from the end of March in 75 Pulse Pharmacies, Vitamin Me and Roy Young stores nationally, as well as online. A dedicated website designed for customers to access the brand (www.elixia.com.au) will offer product information, skincare tips and highlight launch activities and promotions.

“The Elixia™ products have clear superiority and Pulse Pharmacies always relishes being able to offer our customers the best available,” said Mr Rohan Aujard, Chief Executive  Officer of Pulse Pharmacy.

Phosphagenics is commercialising drug delivery applications based on its novel transdermal (drugs administered via skin) TPM™ – Targeted Penetration Matrix technology. TPM™ is a patient friendly and cost effective system used to deliver proven pharmaceutical and nutraceutical products.   The two product targets which are advancing through clinical trials are an insulin patch for diabetics (instead of injections) and an oxycodone patch for the relief of chronic pain.

www.phosphagenics.com

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Phosphagenics Share Purchase Plan

Friday, August 14th, 2009

Phosphagenics  (POH) announced on the 13/8/2009 that they would be conducting a Share Purchase Plan to raise additional capital. The record date is the 20/8/2009 on which shareholders must own the share to participate in the SPP. The closing date is 25/9/2009. Shares will be issued on 6/10/2009 and begin trading on 9/10/2009.  A maximum of $15,000 can be purchased by each shareholder at a 20% discount to the volume weighted average price (VWAP).  The offer is underwritten.

Discount : 20.0% Liquidity : Poor  Profitability : Ok  Stability : Ok

www.phosphagenics.com

* Note: Discount is based on the closing price on the 13 August 2009.

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Phosphagenics Share Purchase Plan

Friday, August 14th, 2009

Phosphagenics (POH) announced on the 13/8/2009 that they would be conducting a Share Purchase Plan to raise additional capital. The record date is the 20/8/2009 on which shareholders must own the share to participate in the SPP. The closing date is 25/9/2009. Shares will be issued on 6/10/2009 and begin trading on 9/10/2009. A maximum of $15,000 can be purchased by each shareholder at a 20% discount to the volume weighted average price (VWAP). The offer is underwritten.

Discount : 20.0% Liquidity : Poor Profitability : Ok Stability : Ok

www.phosphagenics.com

* Note: Discount is based on the closing price on the 13 August 2009.

For More Share Purchase Plans go to http://blog.mdsfinancial.com.au/category/share-purchase-plans/

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Phosphagenics and Metabolic Pharmaceuticals Enter JV

Friday, August 14th, 2009

Phosphagenics Limited (POH) today announced that it has signed a collaborative research and option agreement with Metabolic Pharmaceuticals Limited (MBP). Under the terms of the agreement, Phosphagenics may elect to license Metabolic’s patented compound, AOD9604, for use as a cosmeceutical product aimed at reducing cellulite and subcutaneous fat. If Phosphagenics exercises its option to license the compound, it will pay Metabolic an undisclosed royalty on future sales of the product.

These types of products do not require significant financial resources for research and development and are not subject to the same stringent approval processes as drugs. Should the research prove to be successful, it is expected that a product should be ready for a launch in the second half of 2010.

Dr Esra Ogru said, ”the current leading commercial cosmetic creams aimed at reducing subcutaneous fat are backed by little scientific data or proof of efficacy. An efficacious, anti- fat cream should quickly command the global market. The low cost of entry into the personal care industry and the speed in which products can be launched into the market makes this industry extremely attractive.”

Phosphagenics is a Melbourne-based, globally driven biotechnology company focused on the discovery of new and cost effective ways to enhance the bioavailability, activity, safety and delivery of proven pharmaceutical and nutraceutical products. Phosphagenics’ core technology is built around the science and application of phosphorylation, a process where the addition of a phosphate group has been found to enhance the bioavailability, activity and safety of existing pharmaceuticals and nutraceuticals, as well as to assist in the production of drug delivery platforms.

www.phosphagenics.com

www.metabolic.com.au

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Phosphagenics Successfully Completes Phase 1 Trials

Tuesday, June 30th, 2009

Phosphagenics Limited (POH) today announced the successful completion of its Phase 1 Repeat Insult Patch Test (RIPT) demonstrating that the repeated application of its patented TPM/oxycodone formulation did not cause any significant erythema or sensitisation in humans. Erythema (skin reddening) and sensitization can typically occur when opioids are exposed to the skin and have until now been a limiting factor in commercialising transdermal opioids. With sales exceeding $US 1.5 billion annually, oxycodone is one of the world’s leading pain management drugs, being more potent than morphine with less adverse side effects. Currently it can be administered only orally or intravenously but Phosphagenics is working towards becoming the first company to offer patients suffering from chronic pain a gel or patch that will provide sustained-release of Oxycodone into the bloodstream. As part of these pre-clinical studies, the company conducted animal studies which established that its formula did not cause sensitisation. This was a crucial milestone in its opioid development program but it needed to be verified in humans before the compounds could be commercialized.

RIPT is the standard method for assessing whether a compound is an irritant and/or sensitiser. During the three week induction phase of the study, TPM/Oxycodone was applied every second day to the same area of the subjects’ back and covered with an occlusive dressing. The site of application was assessed every second day after patch removal, and scored for redness and erythema. During the challenge phase which occurred two weeks after the completion of the induction phase, the formulation was applied once to a new area of skin and assessed to determine whether an immune response had developed. The open label, single centre study was conducted at the Royal Adelaide Hospital under the guidance of Principal Investigator, Dr Guy Ludbrook. Fifty healthy, adult volunteers participated in the RIPT trial. The endpoints were the assessment of erythema and sensitisation.

These clinical results pave the way for an extensive Phase 1A pharmacokinetic study examining the transdermal delivery of Oxycodone from Phosphagenics’ TPM/Oxycodone in the recently announced patch systems and also in gels. These studies are expected to commence Q3/09.

www.phosphagenics.com

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