Posts Tagged ‘PGL’

ASX Company News: Progen Pharmaceuticals Enters Diabetes Joint Venture

Thursday, March 31st, 2011

Progen Pharmaceuticals  Limited  (PGL) announced  that  it has entered  into a  Diabetes Collaboration  Framework  Deed with  the  Australian National  University  (ANU)  and  ANU  Enterprise  Pty  Limited.  ANU researchers have  developed  intellectual  property  for  a  new  therapeutic approach  for  the treat ment  of  type 1  diabetes with potential application  in type  2 diabetes. The  collaboration  strategically  builds  on  the  relationship  between  ANU  and  Progen  to progress the commercialisation of the new therapy. ANU will  commercialise  the intellectual property by  establishing a new company  focused  on the  commercial development  of  new  diabetes  therapeutics.  Progen will formally collaborate with the ANU, hold a small stake in the new company, consult with the ANU through an R&D Management  Group  and  provide  research  and  development  services  as  and  when  required on a fee for service basis with the new company.

Prof.  Parish, who leads the Cancer  and Vascular Biology Group at the  John Curtin School of Medical Research, said that: “Type  1  diabetes  is  an  autoimmune  disease  in  which  the  insulin-producing  beta  cells  of pancreatic  islets  are  destroyed.  Our  research  has  led  to  a   new  understanding  of  how pancreatic  islet  cells  including  beta  cells  are  protected  from  metabolic  stress  and autoimmune  attack  in  type  1  diabetes.  It  also  has  implications  for  understanding  similar mechanisms  in  type  2  diabetes.  Ba sed  on  this  novel  discovery  we  have  established  a therapeutic approach  that attenuates the progression of type 1 diabetes.

Progen  Pharmaceuticals  Limited  is  a  biotechnology  company  committed  to  the  discovery, development  and  commercialization  of  small  molecule  pharmaceuticals  primarily  for  the treatment  of  cancer.   Progen’s core focus is development  of  its anti-angiogenesis and anti-metastatic oncology products pipeline.

www.progen-pharma.com

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ASX Company News: Progen Pharmaceuticals Granted US Patent

Wednesday, January 26th, 2011

Progen Pharmaceuticals Ltd (PGL) is pleased to announce the grant of the United States patent entitled “Sulfated Oligosaccharide Derivatives” that protects Progen’s PG500 series of small molecule  compounds.

Progen’s PG500 series of compounds was the result of an internal research programme partially funded by Start and Commercial Ready grants from the Australian Government. This patent protects compounds in Progen’s PG500 series of heparan sulfate mimetic molecules and their use in a variety of therapeutic areas predominantly related to oncology (including solid tumour, angiogenesis and metastasis) but also encompassing inflammation and other indications where heparan sulfate mimetic compounds provide important therapeutic options (coagulation, thrombosis, raised blood triglyceride levels, proliferative retinopathy, HSV-1 infection, or cardiovascular disease) and veterinary uses are also protected.

“Protection of the intellectual property by this patent strengthens and extends our drug development portfolio for the PG500 series technology.” said Ian Bytheway, Director of Research and Development, Progen Pharmaceuticals Ltd. “It is pleasing to announce the granting of this patent in such a commercially important region and it represents an important milestone in our development and commercialisation of PG500 series technology, from which our lead compound PG545 has already commenced human clinical trials.” said Sue MacLeman, Chief Executive Officer, Progen Pharmaceuticals Ltd.

Progen Pharmaceuticals Limited is a biotechnology company committed to the discovery, development and commercialization of small molecule pharmaceuticals primarily for the treatment of cancer. Progen has built a focus and strength in anti-cancer drug discovery and development.

www.progen-pharma.com

http://www.traderdealer.com.au/Fundamentals/pgl

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ASX Company News: Progen Pharmacuticals Receives Order For Liver Cancer Treatment

Monday, November 15th, 2010

Progen Pharmaceuticals Ltd (PGL) are pleased to announce that PI-88 licensee, Medigen Biotechnology Corporation (Medigen), have placed the purchase order for clinical trial materials for the Phase III clinical trial in liver cancer patients.

Progen’s fully owned contract manufacturing subsidiary PharmaSynth Pty Ltd will now commence the manufacturing runs required for the delivery of the PI-88 clinical trial material for this important trial. “This is another step towards the clinic and we are pleased that Medigen is making such good progress with this program to develop and commercialise PI-88” said Sue MacLeman, Chief Executive Officer, Progen Pharmaceuticals Ltd.

PI-88 is a multi-targeted cancer therapeutic in late stage development which inhibits both angiogenesis (or tumour promoting) factors such as Vascular Endothelial Growth Factor (VEGF), Fibroblast Growth Factors (FGF) 1 and 2, and heparanase, an enzyme implicated in metastasis (tumour spread). As previously announced Progen has exclusively licensed the worldwide rights for PI-88 to Medigen for all oncology indications.

www.progen-pharma.com

http://www.traderdealer.com.au/Fundamentals/pgl

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Progen Pharmaceuticals To Manufacture Two Drugs For Zensun

Friday, May 28th, 2010

Progen Pharmaceuticals Ltd (PGL) announced today that the company’s biopharmaceuticals manufacturing subsidiary PharmaSynth Pty Ltd, had secured a new contract with Zensun (Shanghai) Sci & Tech Co Ltd. Zensun has successfully developed two drugs: the Recombinant Human Neuregulin-1 (rhNRG-1) injection, an anti-heart failure drug, and Recombinant Human ErbB3 fragment injection, a therapeutic vaccine against tumours. Both have undergone clinical trials. PharmaSynth has been contracted to manufacture rhNRG-1 for a forthcoming US based phase II clinical trial. PharmaSynth has expertise in recombinant proteins, bacterial and viral vaccines, whole cell therapeutics and small molecule synthesis and has previously manufactured this product for use by Zensun.

PharmaSynth’s CEO Les Tillack said the securing of this new contract demonstrated PharmaSynth’s position as an important Australian based contract manufacturer operating in the global market. “The opportunity to manufacture rhNRG-1 is an exciting one for PharmaSynth. We consider it a privilege to be involved with the development project for such a promising new drug. This project fits well with our core skills in recombinant protein manufacture and demonstrates our abilities as a world class biopharmaceutical contract manufacturing organization,” he said. Progen CEO, Sue MacLeman confirmed PharmaSynth Pty Ltd continued to expand into the global biopharmaceutical manufacturing market through a commitment to quality pharmaceutical manufacturing and flexibile service provision.

Progen Pharmaceuticals Limited is a biotechnology company committed to the discovery, development and commercialization of small molecule pharmaceuticals primarily for the treatment of cancer. Progen has built a focus and strength in anti-cancer drug discovery and development. Progen targets the multiple mechanisms of cancer across its three technology platforms of angiogenesis, epigenetics and cell proliferation. Progen has operations in Australia and the United States of America.  PharmaSynth is a Brisbane, Australia based, drug development and contract manufacturer serving the pharmaceutical, biotechnology and veterinary industries.

Zensun ( Shanghai ) Sci & Tech Co., Ltd. is a bio-tech pharmaceutical company well-versed in the demands of the international market with a high profit potential based on innovation. It is devoted to the research and development of new drugs through self-owned intellectual properties. With adherence to the tenet of “healing for life”, Zensun has long been focusing on the research of anti-tumor drugs and anti-heart failure drugs. Based on the innovative theory, Zensun has successfully developed two drugs: the Recombinant Human Neuregulin- 1 injection, an anti-heart failure drug, and Recombinant Human ErbB3 fragment injection, a therapeutic vaccine against tumors, both have undergone clinical trial. Zensun (Shanghai) Sci & Tech Co Ltd is based in the Peoples Republic of China.

www.progen-pharma.com

www.zensun.com

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Progen Pharmaceuticals Secures Manufacturing Contract

Wednesday, April 21st, 2010

Progen Pharmaceuticals Ltd (PGL) are pleased to announce that the company’s wholly owned subsidiary PharmaSynth Pty Ltd, a contract biopharmaceuticals manufacturing organisation, has secured a new contract with Hunter Immunology Limited. While the details of this agreement are confidential this new contract further validates PharmaSynth Pty Ltd as an important Australian based contract manufacturer with expertise in recombinant proteins, bacterial and viral vaccines, whole cell therapeutics and small molecule synthesis.

Hunter Immunology Ltd is a late stage biopharmaceutical company focused on respiratory markets. Its lead product, HI-164OV is an orally-administered immunotherapeutic aimed at reducing the number and severity of acute bronchitis in moderate to severe COPD (Chronic Obstructive Pulmonary Disease).  “This new contract continues our good relationship with PharmaSynth which successfully produced material for our Phase IIa trial and will provide the active ingredient for our forthcoming Phase IIb trial” said Dr Kevin Healey, Managing Director of Hunter Immunology Ltd.

“”We are pleased that our team at PharmaSynth Pty Ltd has been able to secure this important contract. We look forward to further collaborations with other Australian biopharmaceutical companies and with the recent changes to the R&D Tax credit there are now even more incentives in place for PharmaSynth to work with other companies ” said Sue MacLeman, Chief Executive Officer, Progen Pharmaceuticals Ltd and Managing Director PharmaSynth Pty Ltd.

PharmaSynth has also been engaged to assist in the manufacture of Progen’s new clinical candidate PG545 for a Phase 1 trial expected to start later this year. As part of this, PharmaSynth is expanding its small molecule synthesis capabilities with the purchase of a pilot scale glass reactor train and the installation of a small fill and finish suite to manufacture sterile lyophilised vials.

Les Tillack, PharmaSynth’s CEO said that “This increase in our small molecule synthesis capabilities allows us to actively pursue the early phase synthetic molecule market which we see as an actively growing sector of the Biotech industry. This combined with over 15 years of experience in biopharmaceuticals allows us to potentially service most of the biotech projects in Australia and increasingly overseas.”

www.progen-pharma.com

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Progen To Buy Back 60% of Shares at $1.10

Tuesday, March 10th, 2009

Progen Pharmaceuticals Limited (PGL) has announced a $40m buyback offer (60% of shares) at $1.10 per share.  Only those Progen Shareholders holding Progen Shares at 7.00pm Sydney time on Thursday 19 March 2009 and still holding Progen Shares at the time they lodge their acceptance notice may participate in the off market Buy Back Offer. US and other foreign holders will be able to participate.  As required by the Corporations Act, the Buy Back Offer must be approved by ordinary resolution of Shareholders. 

The proposed timetable for the Buy Back Offer is set out below.

  • Record Date: Thursday 19 March 2009
  • Offer Opens: Monday 23 March 2009
  • General Meeting: Wednesday 22 April 2009
  • Offer Closes: Friday 24 April 2009
  • Announcement: Thursday 30 April 2009
  • Cheques Posted: Wednesday 6 May 2009

Participation in the Buy Back Offer is voluntary. Eligible Progen Shareholders are not obliged to accept the Buy Back Offer.  If Progen receives acceptances for more than $40m, the number of Progen Shares to be bought back from each Progen Shareholder will be scaled back on a pro rata basis having regard to the total number of acceptances. 

http://www.progen.com.au/ 

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